Online Sleep Prescription in Brooklyn

Doxepin – at this dose Doxepin preferentially binds to and blocks histamine receptor sites and exerts the sleep maintenance effect. This compound does not possess common side effects like other antihistamines used for sleep, such as benadryl or diphenhydramine.

Melatonin – a derivative of tryptophan, this neurohormone is produced in the pineal gland during the dark hours of the day-night cycle and binds to receptors that coordinate the sleep-promoting properties associated with circadian rhythms. It has also been found to increase levels of anti-inflammatory interleukins and down-regulates proinflammatory cytokines.

Valeriana Root extract – Valerian root, and particularly valerenic acid, allosterically modulate GABA receptors as the basis of its anxiolytic and sedative properties.

Theanine – an amino acid found in Green Tea that promotes a calm, relaxed state. It confers anti-inflammatory and protective effects in the brain, stomach, and liver and may be converted into the primary inhibitory neurotransmitter GABA.

Magnesium glycinate – At least 300 enzymes dependent upon magnesium for normal functionality, including enzymes involved in neurotransmitter synthesis. Neurons require adequate magnesium to prevent excessive excitation by calcium, which if unchecked may result in depression and anxiety-like behavior. The glycinate moiety supports a relaxed state by serving as an inhibitory neurotransmitter.

Potassium chloride – an important mineral required for the maintenance of the excitatory properties of neuromuscular tissues and is necessary for the induction of sleep in mammalian species. The concentrations of potassium and sodium across cell membranes regulates the excitability of the cell, nerve impulse conduction and body fluid balance.

Cholecalciferol – this vitamin facilitates the maintenance of normal calcium and phosphate concentrations via intestinal calcium and phosphate absorption, mobilization of calcium from bone, and reduction of calcium and phosphate excretion in the kidneys. It is also implicated in the biosynthesis of neurotrophic factors, contributing to neuroprotective pathways with increased glutathione and reduced NO, and involvement in neurotransmitter synthesis including acetylcholine and catecholamines.

Ziziphus spinosa seed – this herb is found in Chinese medicine and exerts a range of sedative and hypnotic actions mediated primarily by the GABA system. Through its modulation and enhancement of the activity of GABA, this herb offers sedative effects.

Magnolia officinalis bark – an herb found in traditional Chinese medicine, Magnolia bark modulates GABA, cannabinoid, and adenosine receptor activity and subsequently reduces anxiety levels. Honokiol and dihydrohonokiol, the two main actors, are described as having anxiolytic action, and subsequent alterations in serotonin turnover in different regions of the brain that results in sleep-promoting effects.

Moringa oleifera leaves – a highly nutritious plant, it exerts a central inhibitory effect by increasing glutamate and serotonin in the prefrontal cortex and decreasing dopamine and norepinephrine in the cerebral cortex, midbrain, and cerebellum. Moringa is a significant CNS depressant that improves sleep and decreases muscle cramps.